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Fructose and mannose metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
D-glucose + NADPH <=> sorbitol + NADP+ 1.1.1.10 L-xylulose reductase
1.1.1.138 mannitol 2-dehydrogenase (NADP+)
1.1.1.19 glucuronate reductase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.72 glycerol dehydrogenase (NADP+)






L-fuconolactone + H2O <=> L-fuconate 3.1.1

protein_Npi-phospho-L-histidine + D-fructose <=> protein_L-histidine + D-Fructose_1-phosphate 2.7.1.202 protein-Npi-phosphohistidine---D-fructose phosphotransferase

D-Allose_6-phosphate <=> D-allulose_6-phosphate 5.3.1.6 ribose-5-phosphate isomerase

ATP + D-allose <=> ADP + D-Allose_6-phosphate 2.7.1.55 allose kinase

L-Rhamnonate <=> H2O + 2-dehydro-3-deoxy-L-rhamnonate 4.2.1.90 L-rhamnonate dehydratase

D-mannose + ATP <=> D-mannose_6-phosphate + ADP + H+ 2.7.1.1 hexokinase
2.7.1.2 glucokinase
2.7.1.4 fructokinase
2.7.1.55 allose kinase
2.7.1.60 N-acylmannosamine kinase
2.7.1.7 mannokinase






GDP-mannose <=> GDP-4-dehydro-6-deoxy-D-mannose + H2O 4.2.1.47 GDP-mannose 4,6-dehydratase

D-mannose <=> D-fructose 5.3.1.15 D-lyxose ketol-isomerase
5.3.1.5 xylose isomerase
5.3.1.7 mannose isomerase
5.3.1.B3




beta-D-fructose_6-phosphate + diphosphate <=> H+ + phosphate + D-fructose_1,6-bisphosphate 2.7.1.90 diphosphate---fructose-6-phosphate 1-phosphotransferase

L-rhamnose + NADP+ <=> L-Rhamno-1,4-lactone + NADPH + H+ 1.1.1.173 L-rhamnose 1-dehydrogenase
1.1.1.377 L-rhamnose 1-dehydrogenase (NADP+)
1.1.1.378 L-rhamnose 1-dehydrogenase [NAD(P)+]



D-glyceraldehyde + ATP <=> H+ + D-glyceraldehyde_3-phosphate + ADP 2.7.1.28 triokinase
2.7.1.29 glycerone kinase


oligosaccharides + H2O <=> D-mannose + oligosaccharides 3.2.1.137 mannan exo-1,2-1,6-alpha-mannosidase
3.2.1.77 mannan 1,2-(1,3)-alpha-mannosidase


H2O + beta-D-fructose_2,6-bisphosphate <=> phosphate + beta-D-fructose_6-phosphate 3.1.3.25 inositol-phosphate phosphatase
3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase


GDP + alpha-D-mannose_1-phosphate + H+ <=> phosphate + GDP-mannose 2.7.7.22 mannose-1-phosphate guanylyltransferase (GDP)
2.7.7.37 aldose-1-phosphate nucleotidyltransferase
2.7.7.69 GDP-L-galactose phosphorylase



2-dehydro-3-deoxy-L-rhamnonate <=> pyruvate + L-lactaldehyde 4.1.2.53 2-keto-3-deoxy-L-rhamnonate aldolase

alpha-D-mannose_1-phosphate <=> D-mannose_6-phosphate 5.4.2.10 phosphoglucosamine mutase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.8 phosphomannomutase



protein_Npi-phospho-L-histidine + L-sorbose <=> protein_L-histidine + L-sorbose_1-phosphate 2.7.1.206 protein-Npi-phosphohistidine---L-sorbose phosphotransferase

2,4-didehydro-3-deoxy-L-rhamnonate + H2O <=> pyruvate + L-lactate + H+ 3.7.1.26 2,4-didehydro-3-deoxy-L-rhamnonate hydrolase

D-fructose + ATP <=> H+ + D-Fructose_1-phosphate + ADP 2.7.1.11 6-phosphofructokinase
2.7.1.3 ketohexokinase


ATP + L-rhamnulose <=> ADP + L-rhamnulose_1-phosphate 2.7.1.5 rhamnulokinase

GDP-mannose + H2O <=> H+ + GMP + alpha-D-mannose_1-phosphate 3.6.1
3.6.1.13 ADP-ribose diphosphatase
3.6.1.21 ADP-sugar diphosphatase
3.6.1.9 nucleotide diphosphatase




D-mannitol + NADP+ <=> D-fructose + NADPH + H+ 1.1.1.138 mannitol 2-dehydrogenase (NADP+)
1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.21 aldose reductase
1.1.1.287 D-arabinitol dehydrogenase (NADP+)
1.1.1.289 sorbose reductase
1.1.1.67 mannitol 2-dehydrogenase






L-rhamnose <=> L-Rhamnofuranose not assigned

ATP + beta-D-fructose_6-phosphate <=> H+ + ADP + D-fructose_1,6-bisphosphate 2.7.1.105 6-phosphofructo-2-kinase
2.7.1.11 6-phosphofructokinase


D-allulose_6-phosphate <=> beta-D-fructose_6-phosphate 5.1.3

D-Fructose_1-phosphate <=> dihydroxyacetone_phosphate + D-glyceraldehyde 4.1.2.13 fructose-bisphosphate aldolase

GDP-mannose + Mannan(n) <=> GDP + Mannan(n+1) 2.4.1

2-dehydro-3-deoxy-L-rhamnonate + NAD+ <=> 2,4-didehydro-3-deoxy-L-rhamnonate + NADH + H+ 1.1.1.401 2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+)

Fructans + H2O <=> D-fructose + Fructans 3.2.1.153 fructan beta-(2,1)-fructosidase
3.2.1.80 fructan beta-fructosidase


ATP + D-Fructose_1-phosphate <=> H+ + ADP + D-fructose_1,6-bisphosphate 2.7.1.11 6-phosphofructokinase
2.7.1.56 1-phosphofructokinase


1,4-beta-D-Mannan + (n-1)_H2O <=> n D-mannose 3.2.1.25 beta-mannosidase
3.2.1.78 mannan endo-1,4-beta-mannosidase


sorbitol + O2 <=> D-glucose + H2O2 1.1.3.40 D-mannitol oxidase
1.1.3.41 alditol oxidase


D-sorbitol_6-phosphate + NAD+ <=> beta-D-fructose_6-phosphate + NADH + H+ 1.1.1.140 sorbitol-6-phosphate 2-dehydrogenase

protein_Npi-phospho-L-histidine + D-mannitol <=> protein_L-histidine + D-mannitol_1-phosphate 2.7.1.197 protein-Npi-phosphohistidine---D-mannitol phosphotransferase

L-rhamnose <=> keto-L-rhamnulose 5.3.1.14 L-rhamnose isomerase
5.3.1.20 ribose isomerase


D-sorbitol + NAD+ <=> D-fructose + NADH + H+ 1.1.1.12 L-arabinitol 4-dehydrogenase
1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.15 D-iditol 2-dehydrogenase
1.1.1.16 galactitol 2-dehydrogenase
1.1.1.21 aldose reductase
1.1.1.9 D-xylulose reductase
1.1.99.21 D-sorbitol dehydrogenase (acceptor)







GDP-6-deoxy-D-talose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+ 1.1.1.135 GDP-6-deoxy-D-talose 4-dehydrogenase
1.1.1.187 GDP-4-dehydro-D-rhamnose reductase


sorbitol + NADP+ <=> L-sorbose + NADPH + H+ 1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.289 sorbose reductase
1.1.1.B60
1.1.99.21 D-sorbitol dehydrogenase (acceptor)




L-fucose <=> L-Fuculose 5.3.1.25 L-fucose isomerase
5.3.1.3 D-arabinose isomerase
5.3.1.4 L-arabinose isomerase



NADPH + L-sorbose_1-phosphate + H+ <=> NADP+ + D-sorbitol_6-phosphate 1.1.1

D-fructose + ATP <=> H+ + beta-D-fructose_6-phosphate + ADP 2.7.1.1 hexokinase
2.7.1.15 ribokinase
2.7.1.2 glucokinase
2.7.1.4 fructokinase




L-Fuculose + ATP <=> H+ + L-Fuculose_1-phosphate + ADP 2.7.1.51 L-fuculokinase

beta-D-fructose_6-phosphate + ATP <=> H+ + beta-D-fructose_2,6-bisphosphate + ADP 2.7.1.105 6-phosphofructo-2-kinase

3-phospho-D-glycerate + GDP-mannose <=> H+ + 2-O-(alpha-D-mannopyranosyl)-3-phospho-D-glycerate + GDP 2.4.1.217 mannosyl-3-phosphoglycerate synthase

L-fucose + ATP <=> L-fucose_1-phosphate + ADP + H+ 2.7.1.52 fucokinase

H2O + D-mannitol_1-phosphate <=> phosphate + D-mannitol 3.1.3.2 acid phosphatase
3.1.3.22 mannitol-1-phosphatase
3.1.3.23 sugar-phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.58 sugar-terminal-phosphatase





GDP-mannose + NAD+ + H2O <=> H+ + GDP-D-mannuronate + NADH 1.1.1.132 GDP-mannose 6-dehydrogenase

D-glucose <=> D-fructose 5.3.1.5 xylose isomerase
5.3.1.9 glucose-6-phosphate isomerase


D-fructose_1,6-bisphosphate <=> dihydroxyacetone_phosphate + D-glyceraldehyde_3-phosphate 4.1.2.13 fructose-bisphosphate aldolase
4.1.2.40 tagatose-bisphosphate aldolase


L-fuconate <=> 2-dehydro-3-deoxy-L-fuconate + H2O 4.2.1.68 L-fuconate dehydratase

GDP-L-fucose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+ 1.1.1.271 GDP-L-fucose synthase

GDP-mannose + 1,4-beta-D-Mannan <=> GDP + 1,4-beta-D-Mannan 2.4.1

L-Fuculose_1-phosphate <=> L-lactaldehyde + dihydroxyacetone_phosphate 4.1.2.17 L-fuculose-phosphate aldolase

D-fructose_1,6-bisphosphate + H2O <=> beta-D-fructose_6-phosphate + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.37 sedoheptulose-bisphosphatase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase




D-Fructose_2-phosphate + H2O <=> D-fructose + phosphate 3.1.3

GDP-6-deoxy-D-mannose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+ 1.1.1.187 GDP-4-dehydro-D-rhamnose reductase
1.1.1.281 GDP-4-dehydro-6-deoxy-D-mannose reductase


H2O + 2-O-(alpha-D-mannopyranosyl)-3-phospho-D-glycerate <=> 2-O-(alpha-D-mannopyranosyl)-D-glycerate + phosphate 3.1.3.70 mannosyl-3-phosphoglycerate phosphatase
3.1.3.85 glucosyl-3-phosphoglycerate phosphatase


L-Rhamnofuranose + NAD+ <=> L-Rhamno-1,4-lactone + NADH + H+ 1.1.1.173 L-rhamnose 1-dehydrogenase
1.1.1.378 L-rhamnose 1-dehydrogenase [NAD(P)+]


GDP-6-deoxy-D-talose + NAD+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+ 1.1.1.135 GDP-6-deoxy-D-talose 4-dehydrogenase
1.1.1.187 GDP-4-dehydro-D-rhamnose reductase


2-dehydro-3-deoxy-L-fuconate + NAD+ <=> 2,4-didehydro-3-deoxy-L-rhamnonate + NADH + H+ 1.1.1

D-glyceraldehyde_3-phosphate <=> dihydroxyacetone_phosphate 5.3.1.1 triose-phosphate isomerase

D-mannitol + 2 ferricytochrome_c <=> D-fructose + 2 ferricytochrome_c + 2 H+ 1.1.2.2 mannitol dehydrogenase (cytochrome)

D-mannitol + NAD+ <=> D-fructose + NADH + H+ 1.1.1.11 D-arabinitol 4-dehydrogenase
1.1.1.138 mannitol 2-dehydrogenase (NADP+)
1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.67 mannitol 2-dehydrogenase




D-sorbitol + FAD <=> FADH2 + L-sorbose 1.1.99.21 D-sorbitol dehydrogenase (acceptor)

H2O + L-Rhamno-1,4-lactone <=> L-Rhamnonate + H+ 3.1.1.65 L-rhamnono-1,4-lactonase

H+ + alpha-D-mannose_1-phosphate + GTP <=> GDP-mannose + diphosphate 2.7.7.13 mannose-1-phosphate guanylyltransferase
2.7.7.28 nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
2.7.7.30 fucose-1-phosphate guanylyltransferase
2.7.7.34 glucose-1-phosphate guanylyltransferase




beta-D-fructose_2,6-bisphosphate + H2O <=> D-Fructose_2-phosphate + phosphate 3.1.3.54 fructose-2,6-bisphosphate 6-phosphatase

GDP-6-deoxy-D-mannose + NAD+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+ 1.1.1.187 GDP-4-dehydro-D-rhamnose reductase
1.1.1.281 GDP-4-dehydro-6-deoxy-D-mannose reductase


ADP-mannose + H2O <=> AMP + D-mannose_1-phosphate 3.6.1.13 ADP-ribose diphosphatase
3.6.1.21 ADP-sugar diphosphatase


GDP-D-mannuronate + polymannuronic_acid_exopolysaccharide <=> polymannuronic_acid_exopolysaccharide + GDP 2.4.1.33 mannuronan synthase

D-threo-aldose + NAD+ <=> L-fuconolactone + NADH + H+ 1.1.1.107 pyridoxal 4-dehydrogenase
1.1.1.116 D-arabinose 1-dehydrogenase (NAD+)
1.1.1.122 D-threo-aldose 1-dehydrogenase



protein_Npi-phospho-L-histidine + D-mannose <=> protein_L-histidine + D-mannose_6-phosphate 2.7.1.191 protein-Npi-phosphohistidine---D-mannose phosphotransferase

L-rhamnulose_1-phosphate <=> L-lactaldehyde + dihydroxyacetone_phosphate 4.1.2.17 L-fuculose-phosphate aldolase
4.1.2.19 rhamnulose-1-phosphate aldolase


alginate <=> Oligouronide_with_4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl_group 4.2.2.11 guluronate-specific alginate lyase
4.2.2.3 mannuronate-specific alginate lyase


protein_Npi-phospho-L-histidine + D-sorbitol <=> protein_L-histidine + D-sorbitol_6-phosphate 2.7.1.198 protein-Npi-phosphohistidine---D-sorbitol phosphotransferase

polymannuronic_acid_exopolysaccharide <=> alginate 5.1.3.37 mannuronan 5-epimerase

GDP-mannose + D-glycerate <=> H+ + 2-O-(alpha-D-mannopyranosyl)-D-glycerate + GDP 2.4.1.269 mannosylglycerate synthase

L-rhamnose + NAD+ <=> L-Rhamno-1,4-lactone + NADH + H+ 1.1.1.173 L-rhamnose 1-dehydrogenase
1.1.1.378 L-rhamnose 1-dehydrogenase [NAD(P)+]


L-fucose_1-phosphate + GTP + H+ <=> GDP-L-fucose + diphosphate 2.7.7.30 fucose-1-phosphate guanylyltransferase

D-mannitol_1-phosphate + NAD+ <=> H+ + beta-D-fructose_6-phosphate + NADH 1.1.1.17 mannitol-1-phosphate 5-dehydrogenase

D-mannose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.8 mannose-6-phosphate isomerase
5.3.1.9 glucose-6-phosphate isomerase


Visualization of the pathway